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It is not known whether amphotericin B amphotericin is excreted in human milk. Though gastrointestinal absorption is insignificant, caution should be exercised when amphotericin B amphotericin is prescribed for a nursing woman.

The effects of this medicine on a person's ability to drive and use machines were not assessed as part of its registration.

Amphotericin is not appreciably absorbed when taken orally, even at high dosage. No systemic adverse effects have followed oral administration of up to at least 3 g daily.

Gastrointestinal disorders. Common: mild gastrointestinal distress; nausea; vomiting; diarrhoea. Skin and subcutaneous tissue disorders. Rare: urticaria, angioedema, Stevens-Johnson syndrome and toxic epidermal necrolysis.

Post marketing surveillance. Skin exfoliation has been reported. Transient yellowing of the teeth may occur with the use of the lozenge formulations, which can easily be removed by brushing.

Reporting suspected adverse effects. Reporting suspected adverse reactions after registration of the medicinal product is important. It allows continued monitoring of the benefit-risk balance of the medicinal product.

Healthcare professionals are asked to report any suspected adverse reactions at www. There is little information available regarding overdose with oral dosage forms of amphotericin B amphotericin.

Since absorption of amphotericin B amphotericin from the gastrointestinal tract is negligible, even in high doses, overdose should not normally result in systemic toxicity.

In case of overdose, usual measures to remove drug substance from the gastrointestinal tract should be considered.

For information on the management of overdose, contact the Poisons Information Centre on 13 11 26 Australia. Mechanism of action. Amphotericin B amphotericin appears to act mainly by interfering with the permeability of the cell membrane of sensitive fungi by binding to sterols, chiefly ergosterol.

It is reported to be fungistatic at concentrations achieved clinically. This medicine is active against a wide range of yeasts and yeast like including Candida albicans.

Candida albicans is generally quite susceptible to the medicine, but other Candida species may be less susceptible. Oral amphotericin B amphotericin has demonstrated antifungal activity towards many fungal species including candidal infections of the oral and perioral areas see Section 4.

Amphotericin B amphotericin is inactive against bacteria including Rickettsia and viruses. Fungal species with decreased susceptibility to amphotericin B amphotericin have been isolated after serial passage in culture media containing the drug, and from some patients receiving prolonged therapy.

Some resistant strains of Candida have been isolated from immunocompromised patients receiving prolonged treatment with amphotericin B amphotericin.

However, strains of Candida albicans resistant to both amphotericin B amphotericin and fluconazole have emerged in a few patients who have received repeated or prolonged courses of fluconazole.

Reports of amphotericin B amphotericin resistant fungi are infrequent. Clinical trials. There is little or no absorption of amphotericin B amphotericin from the gastrointestinal tract.

Each lozenge of Fungilin contains amphotericin B amphotericin , mannitol, acacia, stearic acid, sodium cyclamate, saccharin sodium, polyvinyl alcohol, talc-purified, blood orange flavour T PI , flavour natural orange PI and curacao AP PI Incompatibilities were either not assessed or not identified as part of the registration of this medicine.

The expiry date can be found on the packaging. In Australia, any unused medicine or waste material should be disposed of in accordance with local requirements.

Chemical structure. Molecular weight: CAS number. Reasonable care is taken to provide accurate information at the time of creation.

This information is not intended as a substitute for medical advice and should not be exclusively relied on to manage or diagnose a medical condition.

NPS MedicineWise disclaims all liability including for negligence for any loss, damage or injury resulting from reliance on or use of this information.

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Log in. Forgot password? Consumer medicine information Fungilin Lozenges Amphotericin B amphotericin. See related product images. Consumer medicine information CMI leaflet Please read this leaflet carefully before you start using Fungilin Lozenges.

What is in this leaflet Read this leaflet carefully before taking Fungilin Lozenges. It does not contain all the available information.

It does not take the place of talking to your doctor or pharmacist. If you have any concerns about taking this medicine, ask your doctor or pharmacist.

Keep this leaflet with the medicine. You may need to read it again. What Fungilin is used for Fungilin is a trade name for the antifungal medicine, Amphotericin B.

Before you take Fungilin It is important that you check the information below before you take Fungilin Lozenges. When you must not take them Do not take Fungilin if you have an allergy to it or to any ingredients in the formulation listed at the end of this leaflet.

Do not take Fungilin Lozenges if the packaging is torn or shows signs of tampering. Before you start taking it Tell your pharmacist if: you have allergies to: Amphotericin B or to any ingredients in the formulation listed at the end of this leaflet; any other medicines; substances such as foods, preservatives or dyes.

Symptoms of an allergic reaction may include: swelling of the face, tongue, mouth, lips, throat and difficulty breathing severe and sudden onset of hives or a skin rash.

Fungilin is not recommended for use during pregnancy unless the benefits of treatment outweigh the risks to the unborn baby. It is not known whether Fungilin passes into breast milk.

If you have diabetes, consult with your doctor first before taking Fungilin Lozenges. Taking other medicines Tell your pharmacist if you are taking other medicines, including vitamin and herbal supplements or any medicines you buy without a prescription from your pharmacy, supermarket or health food shop.

How to take Fungilin Use Fungilin only as directed by your doctor or pharmacist. How much to take The recommended daily dose of Fungilin Lozenges is one lozenge, taken four times daily.

How to take it Suck the lozenge and allow it to dissolve slowly in the mouth. When to take it Take Fungilin at about the same time each day, after meals and at bedtime.

How long to take it Continue taking Fungilin Lozenges for days. If you forget to take it If it is almost time for your next dose, skip the dose you missed and take the next dose when you are meant to.

Do not take a double dose to make up for the missed dose. If you are not sure what to do, ask your pharmacist. If you have trouble remembering when to take your medicine, ask your pharmacist for some hints.

If you take too much overdose Taking too many Fungilin Lozenges is unlikely to cause problems. While you are taking Fungilin Things you must do If you are about to start taking any new medicines, tell all doctors and pharmacists who are treating you that you are taking Fungilin Lozenges.

If you become pregnant while using Fungilin Lozenges, tell your doctor immediately. If you plan to have surgery, tell your doctor or dentist that you are taking Fungilin Lozenges.

Things you must not do Do not give Fungilin Lozenges to anyone else, even if they have the same condition as you. Things that may help your condition To avoid the possibility of re-infection or infection of other household members, you must observe strict personal hygiene.

Side effects Tell your doctor or pharmacist as soon as possible if you do not feel well while you are taking Fungilin Lozenges.

Ask your pharmacist to answer any questions you may have. Tell your doctor immediately, or go to the Accident and Emergency Centre at your nearest hospital if you notice any of the following: hives, swelling of the face, mouth, lips, tongue or throat and have difficulty breathing These are very serious side effects.

Tell your doctor if you notice any of the following and they worry you: diarrhoea indigestion or upset stomach nausea vomiting yellowing of the teeth which can be removed by brushing the teeth.

Disposal If your doctor tells you to stop using Fungilin Lozenges, or the lozenges have passed their expiry date, ask your pharmacist what to do with any that is left over.

Product description What it looks like Fungilin Lozenges are round, yellow-coloured, fruit-flavoured lozenge. Ingredients Each lozenge contains: Active ingredients: Amphotericin B amphotericin Other ingredients: mannitol, acacia, stearic acid, sodium cyclamate, sodium saccharin, polyvinyl alcohol, talc purified, blood orange flavour T PI , curacao AP PI , and natural orange flavour PI Fungilin Lozenges do not contain lactose, gluten, tartrazine or any other azo dyes.

Presentation Fungilin Lozenges 10mg Amphotericin B amphotericin lozenge are available in bottles containing 20 lozenges. AUST R Summary Table of Changes.

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